Pathways Bioscience LLC, a biomedical sciences company focused on discovering and developing small molecule drugs and dietary supplements that act on gene transcription pathways, today announced it received a Phase I Small Business Innovation Research (SBIR) grant from the National Institute on Aging (NIA).

The grant will enable Pathways to pursue research on one of its Nrf2 activating dietary supplements, PB125®, for study in aging-related changes in muscle proteostasis, the company said.

PB125 activates the Nuclear Factor, Erythroid 2-Like-2 (NFE2L2, also known as Nrf2) transcription factor pathway, which regulates the expression of a large group of cell protective and anti-inflammatory genes.

“We are happy to be collaborating with Drs. Karyn Hamilton and Ben Miller at Colorado State University with this funding from the National Institute on Aging to evaluate the effects of our Nrf2 activating dietary supplement PB125 on changes in muscle proteostasis that occur during aging,” said Joe M. McCord, Pathways co-founder and scientific leader.

In the project entitled, “Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf2 Activation Pathway,” scientists at Pathways Bioscience are collaborating with Hamilton and Miller at Colorado State University’s Translational Research on Aging and Chronic Disease (TRACD) Laboratory in the Department of Health and Exercise Science.

Part of the research being conducted there focuses on examining the biological determinants of aging and approaches that might slow the aging process. They are examining the hypothesis that proteostatic mechanisms, which are used by the body for maintaining healthy and balanced turnover rates for cellular proteins, may play a key role in controlling the aging process and contribute to healthy aging.

“We are enthusiastic about working with Dr. McCord and Pathways Bioscience to investigate the effects of PB125 and Nrf2 activation on proteostasis and aging.” said Drs. Miller and Hamilton.

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