Advanced Multi-Analyte Optical Biosensor

Opportunity

Available for Licensing
TRL: 7

IP Status

​US Utility Patent: US 9671334

Inventors

Kevin Lear
Tim Erickson

At A Glance

Researchers at Colorado State University have developed a fully portable local evanescent array coupled (LEAC) biosensing platform, capable of performing real time, label-free, multi-analyte, diagnostic assays. This device features an integrated photodetector, exhibits minimal temperature dependence, and requires only a laser diode for waveguide excitation.  The novel aspects of the LEAC biosensor are not merely its experimental sensitivity, but inherently its performing diagnostic assays in resource poor settings.

This platform technology uses photodetector arrays and waveguides on a LEAC biochip that can be functionalized for multi-analyte sensing by patterning different probe molecules in distinct regions of the waveguide. Furthermore, the LEAC chip employs a fully CMOS compatible fabrication scheme, and thus, would be feasible to implement all signal processing on-chip for a wireless link to transmit data to a smartphone or other display device.

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Licensing Director

Mandana Ashouri
Mandana.Ashouri@colostate.edu
970-491-7100

Reference No.:  13-022

Background

​A biochip capable of performing label-free, multi-analyte, diagnostic assays in real time would dramatically improve healthcare delivery in both modern medical facilities and resource poor settings around the globe. Rather than waiting hours or days for lab results, healthcare providers could use such a sensing platform to render a diagnosis in minutes and begin a course of treatment within the same visit.  Real time and accurate sensing is imperative to healthcare providers, as timely results can provide essential data to begin needed care and prevent untimely deaths. This photo-based sensing technology is a good, low-cost solution that fits the needs of all healthcare providers and facilities.

Benefits
  • Improved sensing accuracy and manufacturability of sensor
  • Portable, continuous sensing capabilities with Integrated light source
  • Enables multi-analyte detection in real-time on a single waveguide
  • Hundreds of analytes could be detected on a densely integrated LEAC chip
  • Integration of on-chip signal processing can lead to fully integrated opto-electronic CMOS-compatible biosensor
  • Highly sensitive and accurate results
Applications
  • Healthcare – bedside diagnostics; field work
  • Biosensing
Publications 

T. A. Erickson and K. L. Lear, “Optimization of the Local Evanescent Array-Coupled Optoelectronic Sensing Chip for Enhanced, Portable, Real-Time Sensing,” in IEEE Sensors Journal, vol. 13, no. 5, pp. 1905-1913, May 2013, doi: 10.1109/JSEN.2013.2242058.

Last updated: February 2021

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