Anti-infective Antibacterial Compounds against Mycobacterium tuberculosis and other Mycobacterium Species

Opportunity

Available for Licensing

IP Status

PCT Patent Pending:  WO 2017/184947 A1 (Recent Notice of Allowance)

Inventors

​Richard Slayden
Steven Sucheck
Sandeep Thanna

At A Glance

​Researchers at Colorado State University in collaboration with the University of Toledo have developed new antimicrobial agents that are effective against human and veterinary pathogens, particularly acid-fast organisms such as Mycobacterium tuberculosis. The compounds show improved efficacy and activity well below toxicity to human monocytic cells.  

Licensing Director

Steve Foster
Steve.Foster@colostate.edu
970-491-7100

Reference No.:  2019-120

Background

​​Mycobacterium tuberculosis is an acid-fast gram-positive bacterium that causes tuberculosis (TB). TB ranks first for the number of deaths in humans caused by an infectious agent. It has been difficult to eradicate TB even though the infection is treatable. Treatment for TB takes at least 6 months and, sometimes, up to 2 years. Often, patients do not comply with the entire treatment regimen due to the high numbers of pills per day and the associated side effects. The discontinuation of treatment results in drug resistance. Therefore, there is an immediate need for drugs with improved efficacy and reduced toxicity. 

Benefits
  • Unique composition and possess unique chemistry in preparation of derivatives
  • Exhibit good activity to toxicity ratio (active at concentrations 20-fold lower than toxicity)
  • High potency (MIC = 0.2 – 0.44 µM) against Mycobacterium tuberculosis strains resistant to Isoniazid, Rifampicin and fluoroquinolones. This suggests activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains
Applications
  • Treatment of drug-resistant tuberculosis
  • Treatment of other infections resulting from other Mycobacterium species
Publications

Thanna S et al., Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry, 2016, 14(25):6119-6133

Last updated: April 2020

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