​Copper Enrichment of Titanium and Titania Surfaces

cleaning surfaces

Available for Licensing

IP Status

US Utility Patent Pending (Not Yet Published)


​Ketul C. Popat
Vignesh K Manivasagam
Amit Munshi
Roberta Sabino

At A Glance

Researchers at Colorado State University have developed a novel method to incorporate copper on titanium nanostructured surfaces that present antibacterial properties without being toxic to human cells.  The proposed method is both economical and efficient with applications in biomedical devices and large scale implementation for common household items that frequently come into contact with micro-organisms.

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Licensing Director

Steve Foster

Reference No.:  2021-046


The main properties required of a material for use as a biomaterial are suitable mechanical properties, cell compatibility, blood compatibility, and antibacterial properties. While titanium and its alloys have proven to be highly biocompatible, their surfaces are normally planar, which leads to undesired surface interactions. Research has proven that when the surface of these materials is modified at the nano level it has improved cell adhesion.

To prevent bacteria attachment and colonization on titanium-based implants, many techniques have been proposed such as surface roughening and surface coating. These coatings could be prepared with polymers, silver ions, nanoparticles, or antibacterial drugs. However, there are still some limitations related to these techniques such as loss of bioactivity, local cell toxicity, and bacterial drug resistance that requires further investigation.

  • Surface coating does not change the surface topography of the novel nanostructures (nanotubes and nanoflowers)
  • Enhances cell adhesion and proliferation
  • Improved bacterial toxicity
  • Process is low temperature
  • Biomedical devices (e.g., implants, prosthetics, etc.)
  • Materials common to community gathering places such as furniture, silverware, doorknobs, and fasteners (e.g., objects that come in contact with micro-organisms)
  • May be applied to several metallic, metallic-oxides, or polymer surfaces
Last updated: May 2021
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