Cyclic and Alternating Poly(lactic-co-glycolic acid) Polymers

CA PLGA

A software modeling of a new PLGA
Opportunity

Available for Licensing
TRL: 3

IP Status

US Utility Patent Pending (Not Yet Published)

Inventors

Yaman Peksenar

At A Glance

Researchers at Colorado State University have developed a cyclic and alternating poly(lactic-co-glycolic acid) (PLGA) copolymer. This new PLGA copolymer, CA-PLGA has a uniform degradation profile, which makes it an ideal material for biomedical and drug release applications. The CA-PLGA copolymer also has a higher thermal stability. Block copolymers formed from this cyclic and alternating PLGA may also self-assemble into micelles, which may also be studied for drug delivery devices and biomedical devices.

For more details, please contact our office!

 

 

Licensing Director

Jessy McGowan
Jessy.McGowan@colostate.edu
970-491-7100

Reference No.:  2022-033

Background

Linear poly(lactic-co-glycolic acid) (PLGA) is FDA approved for medical applications. However, linear polymers have chain ends, which is the key starting point of hydrolysis and degradation of linear polymers. These linear polymers thus have an inconsistent drug release profile as most of the drug is delivered too early, due to the quick hydrolysis of the linear polymer chain ends.

 

Technology Overview

The cyclic copolymer units in the new CA-PGLA do not have chain ends, there is a much slower and controlled hydrolysis reaction, leading to a sustained and consistent and uniform drug release profile. Furthermore, traditional purification techniques of polymers lead to by-products. Researchers have optimized the separation of the cyclic polymers from linear contaminants.

Synthesis and methods of CA-PGLA are proprietary, please contact our office to learn more.

Benefits
  • Sustained and uniform drug delivery method
  • No prohibitive increase in viscosity
  • Higher glass transition temperature
  • Potential self-assembly into nanostructures such as micelles
  • Purification and isolation of cyclic ensures copolymer uniformity and predictability
Applications
  • Drug delivery devices
  • Surgical sutures
  • Tissue supports
  • Compostable cups and cutlery

Last updated: June 2022

Add keywords or various names of inventors here (text is hidden)

Polymer, cyclic polymer, macrocycle, PLGA, drug delivery, medical device, biomedical material

Tolmar, johnson and johnson, Pfizer, Bayer, 3M