Areas of Collaborative Interest
Surfaces that contain micro- and nanoscale features in a well-controlled and “engineered” manner have been shown to significantly affect cellular and subcellular function. Within the auspices of the our research program, we are developing, refining and extending select fabrication routes for producing materials with controlled nanoarchitecture and bioactivity, potentially moving us closer to the goal of bio-integration. Of great interest is the creation of controlled micro- and nanoarchitectures in an attempt to mimic the natural physical and biological environment that encourages tissue regeneration and growth. The hypothesis is that the nanoarchitectures can promote cell differentiation and functionality. Moreover, the ability to create model nanodimensional constructs that mimic physiological systems can aid in studying complex tissue interactions in terms of cell communication, response to matrix geometry, and effects of external chemical stimuli. By understanding how physical surface parameters influence cellular adhesion and differentiation we can more effectively design biomaterial surfaces for variety of tissue engineering applications. Further, nanostructured materials can be used as drug eluting interfaces for implantable devices, such as vascular stents, orthopedic implants, dental implants, etc. By precisely controlling the size of nanoarcitecture, we can manipulate the release rates; thus releasing the drug at physiological levels.
I am interested in collaborating in the following areas:
- Titanium Nanomaterials for Orthopedic Implants
- Blood-Contacting Biomaterials for Cardiovascular Medical Devices
- Superhydrophobic and Superhydrophilic Surfaces for Blood Contacting Materials
- Polymeric Nanostructured Surfaces for Tissue Engineering Applications
- Novel Alloys and Surface Treatments or Implants Applications
- Licensing our technologies
Selected Issued & Published Patents
- US10426871B2: Nanostructure surface coated medical implants and methods of using the same*
- US10071186B2, EP2825203B1, AU2013232382B2, CA2866315C, WO2013138240A1: Glycosaminoglycan and synthetic polymer materials for blood-contacting applications
- US10167387B2, WO2015038577A1: Synthetic polymeric materials and devices thereof
- US9597434B2, WO2014169281A1: Surface treatments for vascular stents and methods thereof
- US20180303981A1: Hemocompatibility of superhemophobic titania surfaces **
- BR102014004074A2: surface modification method of titanium alloys and product obtained ***
* Assigned to the University of California & Penn State Research Foundation
** Patent Pending
*** Assigned to the Univ Estadual Paulista Julio D
Patent list generated using Google Patents; Last updated on June 17, 2021.
Hidden text – because the “design” is “light” text:
Ketul Popat, Ketul C. Popat
#CSUInvents – Inventor Highlight! Professor SUSAN JAMES and the team in the #Biomaterials Research and #Engineering Lab in the CSU Walter Scott, Jr. College of Engineering focus on the development and characterization of biomaterials for #cardiovascular and #orthopedic health care. Learn more about Dr. James as an #inventor, her #technologies, and BioPoly LLC.