Ligand Passivated Gold Nanoparticles

Novel Method for the Synthesis of Kinetically Stable Novel Ligand Passivated Gold Nanoclusters
Figure 1. Assembly of Gold Nanoparticles

Available for Licensing

IP Status

US Utility Patent: US 9683992


William Compel
Christopher Ackerson
On Lo Andrea Wong

At A Glance

Researchers at Colorado State University have developed several novel gold nanoclusters and methods for their synthesis.  The unique synthesis produces kinetically stabilized novel gold nanoclusters, in addition to a series of ligand passivated gold nanoclusters that display remarkable physical properties.

Monolayer protected thioloated gold nanoclusters are stable metal nanoparticles that are passivated by a layer of organic material.  Most known syntheses of these gold nanoclusters result in products that have noble-gas-like superatomic electron configuration, such as Au25(SR)18- and Au102(SR)44.  The gold nanoclusters that correspond to the closed-shell configuration are the results of thermodynamic stabilization.  


Licensing Director

Steve Foster

Reference No.: 13-099

  • Ease of reproducibility
  • Scalable from total reaction volumes of µL to mL or more
  • Very fast reaction (takes on average 2% of traditional AuNC syntheses, 1 h vs 48 h)
  • Reaction does not require a “focusing period” (standard methods typically require multiple days)
  • Can be performed at room temperature
  • Provides for new, kinetically-stable compounds not yet previously known
  • High yield (relatively uncommon in this field)
  • Catalysis

  • Optics

  • Fluoresecent probes

  • Theranostics

  • Diagnostics

  • MRI/CT contrast agents

  • Genomics and Biosensorics

  • Immunoassays and clinical chemistry

  • Photothermolysis of cancer cells and tumors

  • Targeted delivery of drugs and antigens

  • Optical bioimaging of cells and tissues

  • Toxic molecule detection

  • Biolabeling

Last updated: May 2020