Areas of Collaborative Interest:
Our research is multidisciplinary and focuses on the molecular design and fabrication of biomimetic materials for use in medical device applications. Biomedical materials development includes the synthesis of prodrugs to simultaneously detect and kill bacteria, glucose biosensing, fabrication of biomass-sourced and biodegradable nitric oxide (NO) releasing polymers, the creation of new pediatric cancer therapeutics, and the creation of new materials to improve extracorporeal membrane oxygenation (ECMO). Our metal-organic frameworks (MOF) research includes the development of next-generation glucose biosensing, fluorescence-based sensing of heavy metals, incorporation of MOFs into biocompatible medical devices, and MOF-based high-performance liquid chromatography (HPLC) separations. Fundamental areas of MOF research include thermal/materials analysis of MOF catalysts, development of flow catalysis systems with MOFs, and kinetic/mechanistic investigations into MOF biocatalysis. Current projects related to analytical method development include generation of liquid chromatography-mass spectrometry (LC-MS) separation and detection methods to analyze the safety and biocompatibility of biodegradable medical devices, fast and easy LC-MS based detection methods for fungal infection biomarkers, and MOF based HPLC separations.
Depending on interests and expertise, we are interested in collaborating in a wide variety of research endeavors including:
- synthesis of molecular, polymer, and extended framework biomaterials containing therapeutic functional groups
- analytical and physical studies of biomaterials utilizing fluorescence, chemiluminesence, zeta potential, and LC/MS-TOF
- mechanistic studies related to the catalytic activity of metal organic frameworks in complex environments
- fabrication and engineering of materials including spin-coating substrates and electrospinning nanofibers for tissue engineering
- in vitro and in vivo efficacy and toxicity studies of biomaterials with potential translation to medical applications (preclinical studies done in collaboration with CSU Veterinary Medicine, Medical Center of the Rockies, and University of Georgia)
- licensing our technologies.
Select Issued and Published Patents
- US20190358618A1, US10406512B2, WO2015164821A1: Metal-organic framework functionalized polymeric compositions
- US20210169082A1, EP3651580A4, WO2019014348A1: Antibacterial surface of metal-organic framework-chitosan composite films
- WO2018191415A1, US20210114011A1: Functionalization of metal-organic frameworks
- US9034355B2, WO2012116177A3: Materials for modulating biological responses and methods of making*
- US10266408B2, US9493352B2, WO2011082164A1, EP2519467B1, US8771756B2: Modular biocompatible materials for medical devices and uses thereof
- US8034384B2, US8168423B2, US7335383B2: Method of increasing biocompatibility of medical device by generating nitric oxide*
- US7763283B2: Nitric oxide (NO) releasing material
*Assignee other than Colorado State University
Patent list generated using Google Patents; Last updated on April 12, 2022.
Melissa Reynolds, Melissa M Reynolds, Melissa M Batchelor