Novel Antibacterial Surfaces

Opportunity

Available for Licensing

IP Status

PCT Patent Pending: WO 2019/014348 A1

Inventors

Melissa Reynolds
Bella Neufeld
Megan Neufeld
Alec Lutzke

At A Glance

Researchers at Colorado State University have developed a composite material that combines the use of a water-stable metal organic framework (MOF) blended with chitosan films to create antibacterial surfaces.  Cellular viability assays performed on the films exhibited a substantial reduction in bacterial attachment (85%) and was maintained for 24 hrs.  These composite materials represent a new approach for a passive antibacterial surface that could ultimately be used to help address the issues facing biofilm formation in clinical settings.

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Licensing Director

Jessica Trostel
J.Trostel@colostate.edu
970-491-7100

Reference No.: 17-069

Background

The prevalence of antibiotic resistant bacteria poses a serious threat to human health, leading to increased and prolonged bacterial infections. While bacteria in the free-floating, planktonic state remain susceptible to traditional antibiotics, the vast majority of bacteria exist in the biofilm state, where many antimicrobial agents are less effective. The Gram-negative bacterium Pseudomonas aeruginosa (P. aeruginosa) is one particularly concerning bacterial strain due to its capacity to rapidly and efficiently form biofilms, as well as its inherent ability to develop resistance to antibiotics. The biofilm life cycle is considered to occur in five stages, with the first two steps consisting of reversible and irreversible attachment of planktonic bacteria onto a surface. Therefore, identifying a material with the inherent properties to ultimately repel or reduce the bacterial adhesion of harmful pathogens represents a promising direction for controlling biofilm formation.

Benefits
  • 85% reduction in bacterial attachment of Pseudomonas aeruginosa
  • Impediment of biofilm formation
  • Film elicited inhibitory effect after multiple experimental rounds, suggesting reusability
Applications
  • Novel biomaterial to be utilized as a passive antibacterial surface in settings with prevalent bacterial infections
  • Biofilm inhibitor
Publications

Neufeld, M. J.; Lutzke, A.; Tapia, J. B.; Reynolds, M. M. Metal-Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S-Nitrosoglutathione in Aqueous Solution. ACS Appl. Mater. Interfaces. 2017, 9(6), 5139-5148. DOI: 10.1021/acsami.6b14937

Neufeld, Bella H., et al. “Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas Aeruginosa.” Wiley Online Library, John Wiley & Sons, Ltd, 24 July 2017, onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201702255.

Neufeld, B. H.; Reynolds, M. M. Critical Nitric Oxide Concentration for Pseudomonas Aeruginosa Biofilm Reduction on Polyurethane Substrates. Biointerphases. 2016, 11, 031012. DOI: 10.1116/1.4962266 **Most read**

Last updated: July 2020

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