Novel Vanadium Complexes to Treat Aggressive Brain Cancer
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US Utility Patent Pending (Not yet Published)
At A Glance
Researchers at Colorado State University in collaboration with University of Sydney have developed novel Vanadium (V) complexes to treat highly aggressive brain cancer via intra-tumoral injection. Preliminary data in various human cancer cell lines (typically treated by intra-tumoral injections) indicate the novel V Complexes have higher cytotoxicity, increased stability and permeability in cell membranes as compared to the anti-cancer drug cisplatin. Furthermore, the V Complexes are consistently more toxic to cancer cells vs. non-cancer cells. These novel V Complexes and decomposition compounds are proprietary.
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Novel therapeutics are required for difficult-to-treat cancers, including brain, lung and pancreatic cancers, in which stabilized formulations of strongly cytotoxic or immune-modulating drugs are injected directly into the tumor via endoscopic procedures. Metal-based drugs, including vanadium (V) complexes, in combination with novel delivery techniques, are promising for anti-cancer treatment. Although, the enhancement of oncolytic viruses by V compounds have shown a remarkable selectivity for cancerous tissue over normal tissue, the extensive reactivity of V complexes in biological media and associated toxicity has been regarded as the main obstacle to their translation into clinical practice. Nevertheless, the limited lifetime of typical V complexes in biological media can be turned into an advantage. Such drugs begin to kill cancer cells immediately after injection into tumors, while their decomposition products released into the blood are less toxic – which is expected to reduce systemic toxicity, a major problem of cancer chemotherapy. Furthermore, decomposition products are likely to prove beneficial, given known anti-diabetic, anti-mutagenic, tissue regeneration promoting and neuro-stimulatory properties of V compounds, all of which can provide simultaneous benefits to many patients.
- Non-toxic decomposition products (i.e., decreased toxicity)
- Increased stability and permeability in cell membranes
- V complex shows immediate death of targeted cells
- Direct injections into tumors allow the use of highly cytotoxic drugs
- Treatment of particularly difficult cancers, e.g. brain cancer
Levina, A, et al. 2020. A Short-Lived but Highly Cytotoxic Vanadium(V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections. Angewandte Chemie International Edition. DOI: 10.1002/anie.202005458
Last updated: Sept 2021