Smart Well Plate for Multi-Analyte Monitoring and Processing


Available for Licensing

IP Status

US Utility Patent Pending (Not Yet Published)


Thomas Chen

At A Glance

Investigators at Colorado State University have developed a Smart well plate that incorporates miniature sensors inside each well to allow real-time monitoring of biological process in each well. The set of sensors can be configured to allow customization. The data can be further augmented using optical images. 

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Licensing Director

Mandana Ashouri

Reference No.:  2019-087


More recently, optical sensors have been used commercially within the custom-designed well plate format to measure oxygen and extracellular acidification rate. They tend to be bulky and expensive without simultaneous multi-analyte monitoring. The smart well plate device is designed to address these shortcomings by providing continuous and simultaneous monitoring of target analytes inside each well for cell culture and small biological samples, as well as providing optical/fluorescent imagery technology for monitoring biomarkers that the sensors cannot provide. 


Tech Overview

The smart well plates have the same size and the same well format as the traditional well plates. The current designs have 6 to 24 well plate format. The smart well plate device consists of two parts: the disposable wells with custom-designed sensors at the bottom of the well; and the plate body with supporting electronics and wireless communication channels. Each well has a glass bottom with gold-plated electrodes. The well wall is a bio-compatible PMMA or CNC material mounted to the glass bottom. Each well in the smart well plate can be individually swapped in and out depending on the type of sensors are needed for a given well. The well is made for one-time use and disposable. The well currently supports sensors for oxygen, glucose, lactate, and pH. Extensions to include glutamine, citrate, and nitrate are currently under development. The electrodes from the sensors are pinned out and connected to the electronic components on the plate body via a pinch-able pins to allow easy swap-in and swap-out of the wells from the device. 

  • Provides continuous monitoring 
  • Provides simultaneous monitoring of target analytes 
  • Wireless interface 
  • Academic Biomedical and Chemistry research Labs 
  • Medical device 
  • Biomedical science education 

Last updated: February 2020

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