Surface Mounted Metal-Organic Frameworks to Filter Uremic Toxin

Opportunity

Available for Licensing

IP Status

US Utility Patent Pending (Not Yet Published)

Inventors

Melissa Reynolds
Hunter Cuchiaro
Jon Thai
Nick Schaffner

At A Glance

Researchers at Colorado State University have developed a new method for the adsorption of uremic toxins utilizing surface mounted metal organic frameworks (SURMOFs) to improve dialysis.  Synthesizing an iron based analog to previously studied zirconium-based MOFs, the group reported three times more uremic toxin (p-cresyl sulfate) was adsorbed with 75% greater adsorption efficiency.  Employing the iron based SURMOF developed here would facilitate industrial applications as the materials are commercially available and easily incorporated into established manufacturing processes. 

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Licensing Director

Jessica Trostel
J.Trostel@colostate.edu
970-491-7100

Reference No.: 2020-042

Background

Kidney failure, also called end stage renal disease (ESRD), is the last stage of chronic kidney disease (CKD) signified by a patients’ kidney functionality falling to only 20%.  Uremia occurs when p-cresyl sulfate, indoxyl sulfate, and other uremic toxins are retained in the blood due to poor kidney function and can lead to liver and heart failure.  Patients who face ESRD, or advanced-stage CKD are ultimately placed on dialysis until a kidney transplant is available to avoid uremia. 

Nearly 11% of the world’s populations have chronic kidney disease, with over 10.5 million people in need of dialysis.  These alarmingly high numbers impose a heavy financial burden on patients in addition to the health care industry, as the annual per-patient cost of dialysis is over $88k in the United States.  With renal disease not slowing down, finding new materials that are more efficient and cost effective is essential to every patients’ overall wellbeing.

Benefits
  • Removes uremic toxins from solution at a lower material cost that current dialytic materials
  • Iron based MOF is water-stable
  • Removes uremic toxin better than its zirconium analog
  • Iron based MOFs are less toxic metals
  • Industrial application is feasible
Applications
  • Biomedical equipment, e.g. dialysis
  • Adsorbent for other applications
Publications

Cuchiaro, Hunter, et al. “Exploring the Parameter Space of p-Cresyl Sulfate Adsorption in Metal–Organic Frameworks.ACS Applied Materials & Interfaces, Apr. 2020, pubs.acs.org/doi/10.1021/acsami.0c04203.

Last updated: July 2020

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