Use of Peptide-Based Inhibitors of the STAT3-IL10 Pathway for Treating Pathogenic Bacterial Infection and Granulomatous Disease
Opportunity
Available for Licensing
IP Status
US Utility Patent: US 10512673
Inventors
Mercedes Gonzalez-Juarrero
Nadya I. Tarasova
Unaltered Image (Left): Chest x-ray showing dense homogenous opacity in right, middle and lower lobe of primary pulmonary TB. Courtesy of (2018). “The Radiological Diagnosis of Pulmonary Tuberculosis (TB) in Primary Care”. Journal of Family Medicine and Disease Prevention 4 (1). DOI:10.23937/2469-5793/1510073. ISSN 24695793. (Image Link)
At A Glance
Researchers at Colorado State University in collaboration with the Department of Health and Human Services have developed and patented a novel treatment of patients infected with pathogenic bacterial infection or granulomatous disease using peptide-based inhibitors reducing persistent infection by more than 90%.
Background
Current chemotherapy for tuberculosis (TB) fails to eliminate rapidly the Mycobacterium tuberculosis bacilli and to control TB globally. Treatment for drug susceptible TB today requires 6-9 months of multidrug therapy. As for TB patients with multi-drug resistant (MDR) – TB infections, treatment is endured for two years and is unsuccessful in more than 50% of the cases. To improve TB control globally, shorter, effective, and well-tolerated treatments for latent TB infection is desired as this is the only way to reduce the development of resistance against the new chemical entities.
Technology Overview
The treatment encompasses a novel utility for IL-10 and STAT3 peptide inhibitors. Data from animal models demonstrated that both STAT3 N-domain and IL-10R peptide inhibitors significantly reduced the persistent infecting Mycobacterium tuberculosis (Mtb) bacilli load in the lungs and modulated the lung host immune response to enhance its own bactericidal capacity infected with Mtb.
Applications
- Commercially valuable therapeutic approach for targeting persistent infecting Mycobacterium tuberculosis (Mtb) bacilli in the lungs
- TB therapy in combination with current standard chemotherapies
Publications
Upadhyay, Rashmi, et al. “Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.” Scientific Reports, Nature Publishing Group UK, 9 Nov. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6226451/.
Last updated: February 2020
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